Publication: Drug resistance and IS6110-RFLP patterns of Mycobacterium tuberculosis in patients with recurrent tuberculosis in northern Thailand.
Accepted Date
2012-10-15
Issued Date
2013-01
Copyright Date
2012
Resource Type
Language
eng
ISSN
0385-5600 (printed)
1348-0421 (electronic)
1348-0421 (electronic)
Rights
Mahidol University
Rights Holder(s)
Microbiology and immunology
Bibliographic Citation
Sukkasem S, Yanai H, Mahasirimongkol S, Yamada N, Rienthong D, Palittapongarnpim P. et al. Drug resistance and IS6110-RFLP patterns of Mycobacterium tuberculosis in patients with recurrent tuberculosis in northern Thailand. Microbiol Immunol. 2013 Jan;57(1):21-9.
Suggested Citation
Supaporn Sukkasem, สุภาพร สุขเกษม, Yanai, Hideki, Surakameth Mahasirimongkol, Yamada, Norio, Dhanida Rienthong, Prasit Palittapongarnpim, ประสิทธิ์ ผลิตผลการพิมพ์, Srisin Khusmith, ศรีสิน คูสมิทธิ์ Drug resistance and IS6110-RFLP patterns of Mycobacterium tuberculosis in patients with recurrent tuberculosis in northern Thailand.. Sukkasem S, Yanai H, Mahasirimongkol S, Yamada N, Rienthong D, Palittapongarnpim P. et al. Drug resistance and IS6110-RFLP patterns of Mycobacterium tuberculosis in patients with recurrent tuberculosis in northern Thailand. Microbiol Immunol. 2013 Jan;57(1):21-9.. doi:10.1111/1348-0421.12000. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/864
Research Projects
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Thesis
Title
Drug resistance and IS6110-RFLP patterns of Mycobacterium tuberculosis in patients with recurrent tuberculosis in northern Thailand.
Corresponding Author(s)
Abstract
The emergence of drug resistant Mycobacterium tuberculosis has become a global
threat to tuberculosis (TB) prevention and control efforts. This study aimed to
determine the drug resistance profiles and DNA fingerprints of M. tuberculosis
strains isolated from patients with relapsed or retreatment pulmonary TB in
Chiang Rai province in northern Thailand. Significant differences in multidrug
resistance (MDR) (P = 0.025) and resistance to isoniazid (P = 0.025) and rifampin
(P = 0.046) between first and second registrations of patients with retreatment
TB were found. However, there were no significant differences in resistance to
any drugs in patients with relapsed TB. The rate of MDR-TB strains was 12.2%
among new patients at first registration, 22.5% among patients with recurrence
who had previously undergone treatment at second registration and 12.5% at third
registration. Two retreatment patients whose initial treatment had failed had
developed MDR-TB with resistance to all TB drugs tested, including rifampin,
isoniazid, streptomycin and ethambutol. IS6110-RFLP analysis revealed that 66.7%
(10/15 isolates) of MDR-TB belonged to the Beijing family. In most cases,
IS6110-RFLP patterns of isolates from the same patients were identical in relapse
and retreatment groups. However, some pairs of isolates from retreatment patients
after treatment failure had non-identical IS6110-RFLP patterns. These results
suggest that, after failure and default treatment, patients with retreatment
tuberculosis have a significantly greater risk of MDR-TB, isoniazid and rifampin
resistance than do other patients.