Publication: Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker
Issued Date
2020-03-01
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ISSN
18793320
09607404
09607404
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2-s2.0-85075026143
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Mahidol University
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SCOPUS
Bibliographic Citation
Surgical Oncology. Vol.32, (2020), 57-62
Suggested Citation
Vorapan Sirivatanauksorn, Wethit Dumronggittigule, Benjamaporn Dulnee, Chatchawan Srisawat, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Patarabutr Masaratana, Chayapol Somboonyosdech, Sirinapa Sripinitchai, Prawat Kositamongkol, Prawej Mahawithitwong, Chutwichai Tovikkai, Pholasith Sangserestid, Somchai Limsrichamrern Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker. Surgical Oncology. Vol.32, (2020), 57-62. doi:10.1016/j.suronc.2019.10.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49629
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Title
Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker
Author(s)
Vorapan Sirivatanauksorn
Wethit Dumronggittigule
Benjamaporn Dulnee
Chatchawan Srisawat
Yongyut Sirivatanauksorn
Ananya Pongpaibul
Patarabutr Masaratana
Chayapol Somboonyosdech
Sirinapa Sripinitchai
Prawat Kositamongkol
Prawej Mahawithitwong
Chutwichai Tovikkai
Pholasith Sangserestid
Somchai Limsrichamrern
Wethit Dumronggittigule
Benjamaporn Dulnee
Chatchawan Srisawat
Yongyut Sirivatanauksorn
Ananya Pongpaibul
Patarabutr Masaratana
Chayapol Somboonyosdech
Sirinapa Sripinitchai
Prawat Kositamongkol
Prawej Mahawithitwong
Chutwichai Tovikkai
Pholasith Sangserestid
Somchai Limsrichamrern
Other Contributor(s)
Abstract
© 2019 Elsevier Ltd Background: Gallbladder cancer (GBC) is a rare and fatal biliary tract malignancy. Genetic derangements are one of many factors that determine the prognosis of GBC. In this study, the expression of the stratifin (SFN) gene encoding 14-3-3 sigma protein, which is reported to be associated with the metastatic property of cholangiocarcinoma cells, was investigated in GBC. Material and methods: Formalin-fixed paraffin-embedded cancer (n = 37) and non-cancer control tissues (n = 14) of gallbladders from patients who underwent surgical resection from January 2006 to May 2015 were retrieved. The expression of SFN normalized with that of ACTB was determined using RT-qPCR. Multivariate analysis of factors affecting disease-free survival (DFS) and overall survival (OS) including the type of SFN expression was performed. Result: The average expression level of SFN in cancer was higher than that in control tissues (p = 0.002). The relative SFN expression in cancer tissue was classified as overexpression (n = 14) and control level expression (n = 23) according to the receiver operating characteristic (ROC) curves for discriminating early GBC recurrence or metastasis after surgery. The SFN overexpression group was associated with lower rates of distant metastasis and early tumor recurrence following resection. The univariate analysis demonstrated factors affecting DFS, including resection margin (p < 0.001), lymphovascular invasion (p = 0.040), perineural invasion (p = 0.046), and SFN expression (p < 0.001). The multivariate analysis revealed that the resection margin (p = 0.019) and SFN expression (P = 0.040) were independent prognostic factors of DFS. Conclusion: To achieve the longest survival, margin-free resection is recommended. The overexpression of SFN in GBC is associated with better prognosis, lower rates of early cancer recurrence, and distant metastasis following resection. SFN expression might be a novel prognostic biomarker in GBC treatment. Further studies to elucidate the role of SFN might unveil its clinical benefit in cancer treatment regimens.