Publication: Human hazard assessment using drosophila wing spot test as an alternative in vivo model for genotoxicity testing—A review
Issued Date
2021-09-01
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ISSN
14220067
16616596
16616596
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2-s2.0-85114766049
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.22, No.18 (2021)
Suggested Citation
Pornsiri Pitchakarn, Woorawee Inthachat, Jirarat Karinchai, Piya Temviriyanukul Human hazard assessment using drosophila wing spot test as an alternative in vivo model for genotoxicity testing—A review. International Journal of Molecular Sciences. Vol.22, No.18 (2021). doi:10.3390/ijms22189932 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76043
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Title
Human hazard assessment using drosophila wing spot test as an alternative in vivo model for genotoxicity testing—A review
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Abstract
Genomic instability, one of cancer’s hallmarks, is induced by genotoxins from endogenous and exogenous sources, including reactive oxygen species (ROS), diet, and environmental pollutants. A sensitive in vivo genotoxicity test is required for the identification of human hazards to reduce the potential health risk. The somatic mutation and recombination test (SMART) or wing spot test is a genotoxicity assay involving Drosophila melanogaster (fruit fly) as a classical, alternative human model. This review describes the principle of the SMART assay in conjunction with its advantages and disadvantages and discusses applications of the assay covering all segments of healthrelated industries, including food, dietary supplements, drug industries, pesticides, and herbicides, as well as nanoparticles. Chemopreventive strategies are outlined as a global health trend for the anti‐genotoxicity of interesting herbal extract compounds determined by SMART assay. The successful application of Drosophila for high‐throughput screening of mutagens is also discussed as a future perspective.