Publication: SERCAP: is the perfect the enemy of the good?
Issued Date
2021-12-01
Resource Type
ISSN
14752875
Other identifier(s)
2-s2.0-85109364252
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Mahidol University
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SCOPUS
Bibliographic Citation
Malaria Journal. Vol.20, No.1 (2021)
Suggested Citation
Nicholas J. White, François H. Nosten SERCAP: is the perfect the enemy of the good?. Malaria Journal. Vol.20, No.1 (2021). doi:10.1186/s12936-021-03821-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77165
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Title
SERCAP: is the perfect the enemy of the good?
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Abstract
Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The operational advantage of a single encounter has to be balanced against the need for a high dose, reliable absorption, little variability in pharmacokinetic properties, slow elimination (to ensure curative drug exposures in all patients) and a very low rate of vomiting. The demanding aspirational target may have hindered anti-malarial drug development. Aiming for three-day regimens, as in current anti-malarial treatments, would be better.