Publication: Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification
Issued Date
2013-04-28
Resource Type
ISSN
2050750X
20507518
20507518
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2-s2.0-84876851369
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Materials Chemistry B. Vol.1, No.16 (2013), 2190-2197
Suggested Citation
Thipvaree Wangchareansak, Arunee Thitithanyanont, Daungmanee Chuakheaw, M. Paul Gleeson, Peter A. Lieberzeit, Chak Sangma Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification. Journal of Materials Chemistry B. Vol.1, No.16 (2013), 2190-2197. doi:10.1039/c3tb00027c Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31538
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Title
Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification
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Abstract
In this work, we apply a molecular imprinting strategy as a screening protocol for different influenza A subtypes, namely H5N1, H5N3, H1N1, H1N3 and H6N1. Molecularly imprinted polymers for each of these subtypes lead to appreciable sensor characteristics on a quartz crystal microbalance leading to detection limits as low as 105particles per ml. Selectivity studies indicate that each virus is preferably incorporated by its own MIP. Recognition in most cases is dominated by the neuraminidase residue rather than the hemagglutinin. Multivariate analysis shows that the sensor responses can be correlated with the differences in hemagglutinin and neuraminidase patterns from databases. This allows for virus subtype characterization and thus rapid screening. © 2013 The Royal Society of Chemistry.