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MAIT cells are activated during human viral infections

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dc.contributor.authorBonnie Van Wilgenburgen_US
dc.contributor.authorIris Scherwitzlen_US
dc.contributor.authorEdward C. Hutchinsonen_US
dc.contributor.authorTianqi Lengen_US
dc.contributor.authorAyako Kuriokaen_US
dc.contributor.authorCorinna Kulickeen_US
dc.contributor.authorCatherine De Laraen_US
dc.contributor.authorSuzanne Coleen_US
dc.contributor.authorSirijitt Vasanawathanaen_US
dc.contributor.authorWannee Limpitikulen_US
dc.contributor.authorPrida Malasiten_US
dc.contributor.authorDuncan Youngen_US
dc.contributor.authorLaura Denneyen_US
dc.contributor.authorMichael D. Mooreen_US
dc.contributor.authorPaolo Fabrisen_US
dc.contributor.authorMaria Teresa Giordanien_US
dc.contributor.authorYe Htun Ooen_US
dc.contributor.authorStephen M. Laidlawen_US
dc.contributor.authorLynn B. Dustinen_US
dc.contributor.authorLing Pei Hoen_US
dc.contributor.authorFiona M. Thompsonen_US
dc.contributor.authorNarayan Ramamurthyen_US
dc.contributor.authorJuthathip Mongkolsapayaen_US
dc.contributor.authorChristian B. Willbergen_US
dc.contributor.authorGavin R. Screatonen_US
dc.contributor.authorPaul Klenermanen_US
dc.contributor.authorEleanor Barnesen_US
dc.contributor.authorJonathan Ballen_US
dc.contributor.authorGary Burgessen_US
dc.contributor.authorGraham Cookeen_US
dc.contributor.authorJohn Dillonen_US
dc.contributor.authorCharles Goreen_US
dc.contributor.authorGraham Fosteren_US
dc.contributor.authorNeil Guhaen_US
dc.contributor.authorRachel Halforden_US
dc.contributor.authorCham Herathen_US
dc.contributor.authorChris Holmesen_US
dc.contributor.authorAnita Hoween_US
dc.contributor.authorEmma Hudsonen_US
dc.contributor.authorWilliam Irvingen_US
dc.contributor.authorSalim Khakooen_US
dc.contributor.authorDiana Koletzkien_US
dc.contributor.authorNatasha Martinen_US
dc.contributor.authorTamyo Mbisaen_US
dc.contributor.authorJane McKeatingen_US
dc.contributor.authorJohn McLauchlanen_US
dc.contributor.authorAlec Minersen_US
dc.contributor.authorAndrea Murrayen_US
dc.contributor.authorPeter Shawen_US
dc.contributor.authorPeter Simmondsen_US
dc.contributor.authorChris Spenceren_US
dc.contributor.authorPaul Targett-Adamsen_US
dc.contributor.authorEmma Thomsonen_US
dc.contributor.authorPeter Vickermanen_US
dc.contributor.authorNicole Zitzmannen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherImperial College Londonen_US
dc.contributor.otherSir William Dunn School of Pathologyen_US
dc.contributor.otherKhon Kaen Regional Hospitalen_US
dc.contributor.otherSongkhla Hospitalen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.contributor.otherOspedale San Bortoloen_US
dc.contributor.otherUniversity of Birminghamen_US
dc.contributor.otherKennedy Institute of Rheumatologyen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherUniversity of Nottinghamen_US
dc.contributor.otherConatus Pharmaceuticalsen_US
dc.contributor.otherUniversity of Dundee College of Medicine, Dentistry and Nursingen_US
dc.contributor.otherHepatitis C Trusten_US
dc.contributor.otherQueen Mary, University of Londonen_US
dc.contributor.otherGilead Sciences Ltden_US
dc.contributor.otherSt. Paul's Hospitalen_US
dc.contributor.otherUniversity of Southamptonen_US
dc.contributor.otherJanssen Diagnosticsen_US
dc.contributor.otherUniversity of California, San Diegoen_US
dc.contributor.otherPublic Health Englanden_US
dc.contributor.otherUniversity of Glasgowen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherNottingham City Hospitalen_US
dc.contributor.otherMerck & Co., Inc.en_US
dc.contributor.otherWellcome Trust Centre for Human Geneticsen_US
dc.contributor.otherMedivir ABen_US
dc.contributor.otherUniversity of Bristolen_US
dc.date.accessioned2018-12-11T02:13:21Z
dc.date.accessioned2019-03-14T08:04:03Z
dc.date.available2018-12-11T02:13:21Z
dc.date.available2019-03-14T08:04:03Z
dc.date.issued2016-06-23en_US
dc.description.abstractMucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation - driving cytokine release and Granzyme B upregulation - is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.en_US
dc.identifier.citationNature Communications. Vol.7, (2016)en_US
dc.identifier.doi10.1038/ncomms11653en_US
dc.identifier.issn20411723en_US
dc.identifier.other2-s2.0-84975705227en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/42998
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84975705227&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.titleMAIT cells are activated during human viral infectionsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84975705227&origin=inwarden_US

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