Publication:
Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

1

Issued Date

2014-11-01

Resource Type

Article

ISSN

10273719

DOI

10.5588/ijtld.14.0106

Other identifier(s)

2-s2.0-84908671644

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

International Journal of Tuberculosis and Lung Disease. Vol.18, No.11 (2014), 1327-1336

Suggested Citation

M. Ballif, V. Nhandu, R. Wood, J. C. Dusingize, E. J. Carter, C. P. Cortes, C. C. McGowan, L. Diero, C. Graber, L. Renner, D. Hawerlander, S. Kiertiburanakul, Q. T. Du, T. R. Sterling, M. Egger, L. Fenner, S. Ajayi, K. Anastos, J. Bashi, W. Bishai, A. Boulle, P. Braitstein, G. Carriquiry, J. E. Carter, P. Cegielski, C. Chimbetete, J. Conrad, M. A. Davies, S. Duda, N. Durier, T. F. Eboua, A. Gasser, E. Geng, L. Hardwicke, C. Hoffmann, R. Huebner, N. Kancheya, P. Kim, D. Lameck, V. Leroy, C. Lewden, M. L. Lindegren, A. Mandalakas, M. Maskew, R. McKaig, L. Mofenson, M. Mpoudi-Etame, B. Okwara, S. Phiri, W. Prasitsuebsai, A. Petit, Hans Prozesky, S. E. Reid, G. Reubenson, A. Sohn, Q. Vo, D. Walker, F. Wehbe, C. Wejse, W. Wester, C. Williams, K. Wools-Kaloustian, Z. Yao, E. Yunihastuti, F. J. Zhang, H. X. Zhao, N. Han, T. P. Merati, D. N. Wirawan Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries. International Journal of Tuberculosis and Lung Disease. Vol.18, No.11 (2014), 1327-1336. doi:10.5588/ijtld.14.0106 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34177

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Journal Issue

Thesis

Title

Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

Author(s)

M. Ballif
 V. Nhandu
 R. Wood
 J. C. Dusingize
 E. J. Carter
 C. P. Cortes
 C. C. McGowan
 L. Diero
 C. Graber
 L. Renner
 D. Hawerlander
 S. Kiertiburanakul
 Q. T. Du
 T. R. Sterling
 M. Egger
 L. Fenner
 S. Ajayi
 K. Anastos
 J. Bashi
 W. Bishai
 A. Boulle
 P. Braitstein
 G. Carriquiry
 J. E. Carter
 P. Cegielski
 C. Chimbetete
 J. Conrad
 M. A. Davies
 S. Duda
 N. Durier
 T. F. Eboua
 A. Gasser
 E. Geng
 L. Hardwicke
 C. Hoffmann
 R. Huebner
 N. Kancheya
 P. Kim
 D. Lameck
 V. Leroy
 C. Lewden
 M. L. Lindegren
 A. Mandalakas
 M. Maskew
 R. McKaig
 L. Mofenson
 M. Mpoudi-Etame
 B. Okwara
 S. Phiri
 W. Prasitsuebsai
 A. Petit
 Hans Prozesky
 S. E. Reid
 G. Reubenson
 A. Sohn
 Q. Vo
 D. Walker
 F. Wehbe
 C. Wejse
 W. Wester
 C. Williams
 K. Wools-Kaloustian
 Z. Yao
 E. Yunihastuti
 F. J. Zhang
 H. X. Zhao
 N. Han
 T. P. Merati
 D. N. Wirawan

Other Contributor(s)

Institut fur Sozial- und Praventivmedizin
 Centre for Infectious Disease Research in Zambia
 University of Cape Town
 Women's Equity in Access to Care and Treatment
 Academic Model Providing Access to Healthcare
 Facultad de Medicina de la Universidad de Chile
 Vanderbilt University
 University of Ghana
 Centre Intégré de Recherches Biocliniques
 Mahidol University
 Children's Hospital
 Universitat Basel
 Beijing Ditan Hospital
 Universitas Udayana
 Gokila
 The HIV Netherlands Australia Thailand Research Collaboration
 TAHOD Steering Committee
 Research Institute for Health Sciences
 Bach Mai Hospital
 National Hospital for Tropical Diseases
 Foundation for AIDS Research
 University of New South Wales (UNSW) Australia
 TApHOD Steering Committee
 Penang Hospital
 Khon Kaen University
 TREAT Asia
 Albert Einstein College of Medicine of Yeshiva University
 Newlands Clinic
 Aurum Institute for Health Research
 Lighthouse Trust
 Tygerberg Hospital
 Desmond Tutu HIV Centre
 Centre National Hospitalier et Universitaire (CHNU)
 Centre Intégré de Recherches Biocliniques d'Abidjan
 Korle Bu Teaching Hospital
 Bandim Health Project
 Otu University
 Operational and Statistical Team

Abstract

© 2014 The Union. SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/34177

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