Publication: Inhibitory effect of cytochalasin E on galactose absorption in the mouse in vitro
Issued Date
1982-12-01
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ISSN
00345164
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2-s2.0-0020383823
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Mahidol University
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SCOPUS
Bibliographic Citation
Research Communications in Chemical Pathology and Pharmacology. Vol.38, No.2 (1982), 247-251
Suggested Citation
T. Glinsukon, C. Toskulkao, P. Piyachaturawat Inhibitory effect of cytochalasin E on galactose absorption in the mouse in vitro. Research Communications in Chemical Pathology and Pharmacology. Vol.38, No.2 (1982), 247-251. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30411
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Title
Inhibitory effect of cytochalasin E on galactose absorption in the mouse in vitro
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Abstract
The inhibitory effect of cytochalasin E on galactose absorption in everted sacs of mouse jejunum was studied. Cytochalasin B had highest potency on the inhibition of galactose absorption when it was added in the mucosal solution followed by cytochalasins E, A, C and D respectively. Cytochalasin E at a concentration as low as 2.5 μg/ml could inhibit galactose absorption by 17.1% within 60 min incubation and its maximum inhibition was obtained at a concentration of 10.0 μg/ml. At this concentration, it inhibited both Na+-dependent and independent galactose absorption. Our results in the present study and previously reported indicate that cytochalasin E inhibits the active intestinal absorption of galactose as well as glucose in the mouse.