Publication: No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells
Issued Date
2004-07-01
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ISSN
01252208
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2-s2.0-4444248880
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.87, No.7 (2004), 816-818
Suggested Citation
Kawin Leelawat, Surang Engprasert, Urai Pongchai-Rerk, Supatip Tuchinda, Cheepsumon Suthipintawong, Vijittra Leardkamolkarn No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells. Journal of the Medical Association of Thailand. Vol.87, No.7 (2004), 816-818. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21614
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Title
No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells
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Abstract
Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.