Publication: Hb tak and Hb Q-Thailand in thai patients are S-window hemoglobin variants revealed by high performance liquid chromatography
| dc.contributor.author | Sumalee Jindadamrongwech | en_US |
| dc.contributor.author | Noppawan Tungbuppha | en_US |
| dc.contributor.author | Suporn Chuncharunee | en_US |
| dc.contributor.author | Punnee Butthep | en_US |
| dc.contributor.other | Faculty of Medicine, Ramathibodi Hospital, Mahidol University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-09-24T08:46:30Z | |
| dc.date.available | 2018-09-24T08:46:30Z | |
| dc.date.issued | 2010-04-01 | en_US |
| dc.description.abstract | The S-window hemoglobin (Hb) variants revealed by high performance liquid chromatography (HPLC) were studied in 12 Thai individuals. The variants were identified, using DNA sequencing and multiplex amplification refractory mutation system-polymerase chain reaction (ARMS-PCR), to be six cases of Hb Tak [β147 (AC)], and six cases of Hb Q-Thailand [α74(EF3)Asp→His], respectively. By using the Capillarys 2-capillary zone electrophoresis (CE), Hb Tak and Hb Q-Thailand co-migrated with Hb F in zone 7. This might pose a problem as the high Hb F conditions suggest a differential diagnosis. The S-window Hb variants are mostly Hb Tak and Hb Q-Thailand in the Thai population rather than Hb S [β6(A3)Glu→Val]. The definite identification of Hb variants detected by HPLC or capillary electrophoresis (CE) requires DNA analysis. © Informa UK, Ltd. | en_US |
| dc.identifier.citation | Hemoglobin. Vol.34, No.2 (2010), 161-164 | en_US |
| dc.identifier.doi | 10.3109/03630261003679631 | en_US |
| dc.identifier.issn | 1532432X | en_US |
| dc.identifier.issn | 03630269 | en_US |
| dc.identifier.other | 2-s2.0-77950482755 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/28743 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950482755&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Medicine | en_US |
| dc.title | Hb tak and Hb Q-Thailand in thai patients are S-window hemoglobin variants revealed by high performance liquid chromatography | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950482755&origin=inward | en_US |