Publication:
Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis

Issued Date

2020-11-01

Resource Type

Article

ISSN

14620332

DOI

10.1093/rheumatology/keaa240

Other identifier(s)

2-s2.0-85094932332

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Rheumatology (Oxford, England). Vol.59, No.11 (2020), 3505-3514

Suggested Citation

Jessica Tibaldi, Angela Pistorio, Elena Aldera, Laura Puzone, Yasser El Miedany, Priyankar Pal, Prabhas Prasun Giri, Hriday De, Raju Khubchandani, Pallavi Pimpale Chavan, Soamarat Vilaiyuk, Butsabong Lerkvaleekul, Jutamas Yamsuwan, Tapas K. Sabui, Pragati Datta, Manuela Pardeo, Claudia Bracaglia, Sujata Sawhney, Sumidha Mittal, Waleed A. Hassan, Ghada Farouk Elderiny, Mohammed Hassan Abu-Zaid, Mervat Eissa, Flavio Sztajnbok, Fernanda C. das Neves Sztajnbok, Ricardo Russo, María Martha Katsicas, Rolando Cimaz, Edoardo Marrani, Ekaterina Alexeeva, Tatyana M. Dvoryakovskaya, Motasem O. Alsuweiti, Ra'ed M. Alzyoud, Mikhail Kostik, Irina Chikova, Francesca Minoia, Giovanni Filocamo, Yomna Farag, Hala Lotfy, Samah Ismail Nasef, Sulaiman M. Al-Mayouf, Maria Cristina Maggio, Claudia Saad Magalhaes, Romina Gallizzi, Giovanni Conti, Masaki Shimizu, Adele Civino, Enrico Felici, Gabriella Giancane, Nicolino Ruperto, Alessandro Consolaro, Angelo Ravelli Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis. Rheumatology (Oxford, England). Vol.59, No.11 (2020), 3505-3514. doi:10.1093/rheumatology/keaa240 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60037

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Title

Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis

Author(s)

Jessica Tibaldi
 Angela Pistorio
 Elena Aldera
 Laura Puzone
 Yasser El Miedany
 Priyankar Pal
 Prabhas Prasun Giri
 Hriday De
 Raju Khubchandani
 Pallavi Pimpale Chavan
 Soamarat Vilaiyuk
 Butsabong Lerkvaleekul
 Jutamas Yamsuwan
 Tapas K. Sabui
 Pragati Datta
 Manuela Pardeo
 Claudia Bracaglia
 Sujata Sawhney
 Sumidha Mittal
 Waleed A. Hassan
 Ghada Farouk Elderiny
 Mohammed Hassan Abu-Zaid
 Mervat Eissa
 Flavio Sztajnbok
 Fernanda C. das Neves Sztajnbok
 Ricardo Russo
 María Martha Katsicas
 Rolando Cimaz
 Edoardo Marrani
 Ekaterina Alexeeva
 Tatyana M. Dvoryakovskaya
 Motasem O. Alsuweiti
 Ra'ed M. Alzyoud
 Mikhail Kostik
 Irina Chikova
 Francesca Minoia
 Giovanni Filocamo
 Yomna Farag
 Hala Lotfy
 Samah Ismail Nasef
 Sulaiman M. Al-Mayouf
 Maria Cristina Maggio
 Claudia Saad Magalhaes
 Romina Gallizzi
 Giovanni Conti
 Masaki Shimizu
 Adele Civino
 Enrico Felici
 Gabriella Giancane
 Nicolino Ruperto
 Alessandro Consolaro
 Angelo Ravelli

Other Contributor(s)

Ospedale Vito Fazzi
 Azienda Ospedaliero Universitaria Meyer
 Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo
 Alexandria University
 Università degli Studi di Milano
 Benha University
 Università degli Studi di Genova
 Kanazawa University
 Sir Ganga Ram Hospital
 Suez Canal University
 Saint Petersburg State Pediatric Medical University
 IRCCS Ospedale Pediatrico Bambino Gesù
 Università degli Studi di Palermo
 King Faisal Specialist Hospital and Research Centre
 IRCCS Istituto Giannina Gaslini - Ospedale Pediatrico
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Ain Shams University, Faculty of Medicine
 Università degli Studi di Messina, Facoltà di Medicina e Chirurgia
 University of Tanta
 Cairo University
 Sechenov First Moscow State Medical University
 Ospedale Maggiore Policlinico Milano
 UNESP-Universidade Estadual Paulista
 Universidade do Estado do Rio de Janeiro
 Medical College and Hospital Kolkata
 Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
 Universidade Federal do Rio de Janeiro
 SRCC Children's Hospital
 Queen Rania Children Hospital
 Institute of Child Health
 National Medical Research Center of Children’s Health

Abstract

© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com. OBJECTIVE: To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity. METHODS: The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding to the four items of the original JADAS a fifth item that aimed to quantify the activity of systemic features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit or at the time of a flare, who had active systemic manifestations, which should include fever. Patients were reassessed 2 weeks to 3 months after baseline. Three versions were examined, including ESR, CRP or no acute-phase reactant. RESULTS: A total of 163 patients were included at 30 centres in 10 countries. The sJADAS was found to be feasible and to possess face and content validity, good construct validity, satisfactory internal consistency (Cronbach's alpha 0.64-0.65), fair ability to discriminate between patients with different disease activity states and between those whose parents were satisfied or not satisfied with illness outcome (P < 0.0001 for both), and strong responsiveness to change over time (standardized response mean 2.04-2.58). Overall, these properties were found to be better than those of the original JADAS and of DAS for RA and of Puchot score for adult-onset Still's disease. CONCLUSION: The sJADAS showed good measurement properties and is therefore a valid instrument for the assessment of disease activity in children with sJIA. The performance of the new tool should be further examined in other patient cohorts that are evaluated prospectively.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/60037

Collections

Scopus 2020