Publication: Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts
Issued Date
2014-01-01
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ISSN
10985522
00199567
00199567
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2-s2.0-84906070895
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Mahidol University
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SCOPUS
Bibliographic Citation
Infection and Immunity. Vol.82, No.9 (2014), 3880-3890
Suggested Citation
Pornpimon Angkasekwinai, Nuntarat Sringkarin, Oratai Supasorn, Madtika Fungkrajai, Yui Hsi Wang, Methee Chayakulkeeree, Popchai Ngamskulrungroj, Nasikarn Angkasekwinai, Kovit Pattanapanyasat Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts. Infection and Immunity. Vol.82, No.9 (2014), 3880-3890. doi:10.1128/IAI.01773-14 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34086
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Title
Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts
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Abstract
Cryptococcal infections are primarily caused by two related fungal species: Cryptococcus neoformans and Cryptococcus gattii. It is well known that C. neoformans generally affects immunocompromised hosts; however, C. gattii infection can cause diseases in not only immunocompromised hosts but also immunocompetent individuals. While recent studies suggest that C. gattii infection could dampen pulmonary neutrophil recruitment and inflammatory cytokine production in immunocompetent hosts, the impact of C. gattii infection on the development of their adaptive T helper cell immune response has not been addressed. Here, we report that C. neoformans infection with highly virulent and less virulent strains preferentially induced pulmonary Th1 and Th17 immune responses in the host, respectively. However, fewer pulmonary Th1 and Th17 cells could be detected in mice infected with C. gattii strains. Notably, dendritic cells (DC) in mice infected with C. gattii expressed much lower levels of surface MHC-II and Il12 or Il23 transcripts and failed to induce effective Th1 and Th17 differentiation in vitro. Furthermore, the expression levels of Ip10 and Cxcl9 transcripts, encoding Th1-attracting chemokines, were significantly reduced in the lungs of mice infected with the highly virulent C. gattii strain. Thus, our data suggest that C. gattii infection dampens the DC-mediated effective Th1/Th17 immune responses and downregulates the pulmonary chemokine expression, thus resulting in the inability to mount protective immunity in immunocompetent hosts. © 2014, American Society for Microbiology.