Publication: Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana
Issued Date
2011-06-01
Resource Type
ISSN
00319422
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2-s2.0-79955757528
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.72, No.9 (2011), 909-915
Suggested Citation
Panomwan Panseeta, Kanlaya Lomchoey, Samran Prabpai, Palangpon Kongsaeree, Apichart Suksamrarn, Somsak Ruchirawat, Sunit Suksamrarn Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana. Phytochemistry. Vol.72, No.9 (2011), 909-915. doi:10.1016/j.phytochem.2011.03.003 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11316
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Title
Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana
Abstract
Investigation of the MeOH extract obtained from the root of the Ziziphus mauritiana grown in Thailand resulted in the isolation of two 14- and 13-membered cyclic alkaloids, mauritine L (1) and mauritine M (2), and three known cyclopeptide alkaloids, nummularines H (3), B (4) and hemsine A (5). Their structures were elucidated on the basis of extensive NMR spectroscopic analysis. The first single crystal X-ray diffraction study of the 13-membered ring cyclopeptide, nummularine B methiodide (4′), revealed all S configurations on the amino acid residues. The isolated alkaloids exhibited potent antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC 50 ) ranging from 3.7 to 10.3 μM. Compounds 2 and 3 also demonstrated antimycobacterial activity against Mycobacterium tuberculosis with the MIC of 72.8 and 4.5 μM, respectively. © 2011 Elsevier Ltd. All rights reserved.
