Publication: The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. On Fasciola gigantica
Issued Date
2017-12-01
Resource Type
ISSN
14698161
00311820
00311820
Other identifier(s)
2-s2.0-85047061516
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Parasitology. Vol.144, No.14 (2017), 1931-1942
Suggested Citation
Panat Anuracpreeda, Runglawan Chawengkirttikul, Arin Ngamniyom, Busaba Panyarachun, Panupong Puttarak, Preeyaporn Koedrith, Noppadol Intaratat The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. On Fasciola gigantica. Parasitology. Vol.144, No.14 (2017), 1931-1942. doi:10.1017/S0031182017001445 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41375
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. On Fasciola gigantica
Abstract
© Cambridge University Press 2017. At present, there are no medicinal plant extracts currently available for treatment and control of fasciolosis. The present work could provide, for the first study, conclusions on the in vitro fasciolicidal properties of the ethanol extract of Terminalia catappa L. (TcCE) leaves against adult Fasciola gigantica after incubation with RPMI-1640 medium containing the TcCE at various concentrations and times when compared with triclabendazole (TCZ). The relative motility and survival index values of the TcCE-treated flukes decreased at a more rapid rate than the TCZ-treated flukes. The death of the parasites was observed after exposed to TcCE at 3 h incubation with 400, 800 and 1000 μg mL-1, and at 6 h incubation in 100 and 200 μg mL-1. Vacuolization, blebbings and partial disruption on the parasites' tegument were observed by light microscopy. When examined by scanning electron microscopy, TcCE caused similar tegumental alterations in the parasites as those observed in TCZ treatment but with larger damage at comparative incubation periods, consisting of swelling, blebbing, disrupted blebs, loss of spines, leading to the erosion, lesion and eventual disruption of the total tegument. Therefore, the TcCE may exert its fasciolicidal effect against F. gigantica by initially causing the tegumental alteration.