Publication: Toward one-pot lipase-catalyzed synthesis of poly(e-caprolactone) particles in aqueous dispersion
Issued Date
2014-01-01
Resource Type
ISSN
18734367
09277765
09277765
Other identifier(s)
2-s2.0-84885036026
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Mahidol University
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SCOPUS
Bibliographic Citation
Colloids and Surfaces B: Biointerfaces. Vol.113, (2014), 254-260
Suggested Citation
Pranee Inprakhon, Pabhangkon Panlawan, Thunyarat Pongtharankul, Emmanuelle Marie, Lars O. Wiemann, Alain Durand, Volker Sieber Toward one-pot lipase-catalyzed synthesis of poly(e-caprolactone) particles in aqueous dispersion. Colloids and Surfaces B: Biointerfaces. Vol.113, (2014), 254-260. doi:10.1016/j.colsurfb.2013.09.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33457
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Title
Toward one-pot lipase-catalyzed synthesis of poly(e-caprolactone) particles in aqueous dispersion
Abstract
The preparation of polyester particles using enzyme-catalyzed (lipase from Candida antarctica B, CALB) ring-opening polymerization of e-caprolactone (e-CL) in aqueous dispersion was demonstrated for the first time. Immobilization of CALB enabled a significant increase of the number-average degree of polymerization of e-CL oligomers (up to 38) as compared to dissolved CALB (8 at the maximum). The nature and amount of lipase, as well as the nature of the support material were identified as key parameters controlling ring-opening polymerization of e-CL in aqueous dispersion. In addition, the involvement of solubilized monomers in polymerization elementary reactions was demonstrated and the consequences on oligomers average length were detailed. An overall mechanism of lipase-catalyzed e-CL polymerization in aqueous dispersion taking into account the colloidal nature of reaction medium was proposed on the basis of experimental results. © 2013 Elsevier B.V.