Publication: Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome
Issued Date
2018-05-01
Resource Type
ISSN
17520371
17520363
17520363
Other identifier(s)
2-s2.0-85046833886
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Mahidol University
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SCOPUS
Bibliographic Citation
Biomarkers in Medicine. Vol.12, No.5 (2018), 465-473
Suggested Citation
Piyaporn Karuwanarint, Benjaluck Phonrat, Anchalee Tungtrongchitr, Kanjana Suriyaprom, Somlak Chuengsamarn, Florian J. Schweigert, Rungsunn Tungtrongchitr Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome. Biomarkers in Medicine. Vol.12, No.5 (2018), 465-473. doi:10.2217/bmm-2018-0029 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45182
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Title
Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome
Abstract
© 2018 2018 Future Medicine Ltd. Aim: To investigate the relationship of Vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-Type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.