Publication:
Challenging regimen for long-term conservative treatment of endometrial adenocarcinoma in young women: A case report and review of the literature

Issued Date

2010-09-01

Resource Type

Review

ISSN

16626575

DOI

10.1159/000321731

Other identifier(s)

2-s2.0-78751526394

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Case Reports in Oncology. Vol.3, No.3 (2010), 380-385

Suggested Citation

Prasong Tanmahasamut, Thanyarat Wongwananuruk Challenging regimen for long-term conservative treatment of endometrial adenocarcinoma in young women: A case report and review of the literature. Case Reports in Oncology. Vol.3, No.3 (2010), 380-385. doi:10.1159/000321731 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29536

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Challenging regimen for long-term conservative treatment of endometrial adenocarcinoma in young women: A case report and review of the literature

Author(s)

Prasong Tanmahasamut
 Thanyarat Wongwananuruk

Other Contributor(s)

Mahidol University

Abstract

A 20-year-old obese Thai woman with polycystic ovary syndrome and clinical stage I well-differentiated endometrial carcinoma denied surgical staging. Chest X-ray and magnetic resonance imaging of the whole abdomen suggested neither distance metastasis nor local invasion of the cancer. After 3 months of systemic progestin therapy with megestrol acetate (MA) 480 mg/day, the endometrial carcinoma persisted. The treatment was changed to a combination of levonorgestrel intrauterine system (LNG-IUS) and MA with a stepping-up from 160 to 480 mg/day. Complete remission was achieved at treatment month 9. Prevention of recurrence was provided using LNG-IUS plus MA 160 mg/day. Endometrial surveillance using trimonthly transvaginal ultrasonography and endometrial biopsy suggested no recurrence for at least 24 months after remission. © 2010 S. Karger AG, Basel.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/29536

Collections

Scopus 2006-2010