Publication: Molecular basis of human cerebral malaria development
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Issued Date
2016-09-27
Resource Type
ISSN
13494147
13488945
13488945
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2-s2.0-84988962730
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Mahidol University
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SCOPUS
Bibliographic Citation
Tropical Medicine and Health. Vol.44, No.1 (2016), 2401-2407
Suggested Citation
Saw Thu Wah, Hathairad Hananantachai, Usanee Kerdpin, Chotiros Plabplueng, Virapong Prachayasittikul, Pornlada Nuchnoi Molecular basis of human cerebral malaria development. Tropical Medicine and Health. Vol.44, No.1 (2016), 2401-2407. doi:10.1186/s41182-016-0033-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/41128
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Title
Molecular basis of human cerebral malaria development
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Abstract
© 2016 The Author(s). Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.