Publication: Cytotoxic glycosphingolipid from Murdannia loriformis (Hassk.) Rolla Rao et Kammathy
52
52
Issued Date
1998
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
509 KB
ISSN
0858-9399
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Mahidol University
Rights Holder(s)
Faculty of Pharmacy Mahidol University
Bibliographic Citation
Thai Journal of Phytopharmacy. 1998; Vol.5, No.1 (1998), 10-20.
Suggested Citation
Weena Jiratchariyakul, Primchanien Moongkarndi, Frahm, A.W., วีณา จิรัจฉริยากูล, Okabe, H., ปริ่มเฉนียน มุ่งการดี Cytotoxic glycosphingolipid from Murdannia loriformis (Hassk.) Rolla Rao et Kammathy. Thai Journal of Phytopharmacy. 1998; Vol.5, No.1 (1998), 10-20.. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/62113
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Title
Cytotoxic glycosphingolipid from Murdannia loriformis (Hassk.) Rolla Rao et Kammathy
Other Contributor(s)
Abstract
Murdannia lorifurmis (Hassk.) Rolla Rao et Kammathy has been traditionally used in
Thailand for the treatment of cancer. The present work was aimed at investigating the active
principles of this plant. Successive extractions of the powdered drug with petroleum ether
(40-60 C), chloroform and ethanol and repeated separation of the ethanolic extract on Diaion HP20
column gave the two c)rtotoxic fractions, namely the methanolic and ethyl acetate fractions. The
methanolic fraction was found to contain an active glycosphingolipid, named 1-beta-O-D-glucopyranosyl-2-(2'-hydroxy-6'-ene-cosamide)-sphingosine. The glycosphingolipid exerted a cytotoxicity effect (EDroof l6 micro/ml) against human colon carcinoma (SW 620) and human
breast cancer ATCC HTB20 (BT 474) cell lines.
Sponsorship
NRCT-JSPS fellowships