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Cytotoxic glycosphingolipid from Murdannia loriformis (Hassk.) Rolla Rao et Kammathy

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dc.contributor.authorWeena Jiratchariyakul
dc.contributor.authorPrimchanien Moongkarndi
dc.contributor.authorFrahm, A.W.
dc.contributor.authorวีณา จิรัจฉริยากูล
dc.contributor.authorOkabe, H.
dc.contributor.authorปริ่มเฉนียน มุ่งการดี
dc.contributor.otherMahidol University. Faculty of Pharmacy.
dc.date.accessioned2010-03-31T03:29:35Zen
dc.date.accessioned2011-08-29T10:40:17Z
dc.date.accessioned2021-05-07T07:46:55Z
dc.date.available2010-03-31T03:29:35Zen
dc.date.available2011-08-29T10:40:17Z
dc.date.available2021-05-07T07:46:55Z
dc.date.created2010-03-31en
dc.date.issued1998en
dc.description.abstractMurdannia lorifurmis (Hassk.) Rolla Rao et Kammathy has been traditionally used in Thailand for the treatment of cancer. The present work was aimed at investigating the active principles of this plant. Successive extractions of the powdered drug with petroleum ether (40-60 C), chloroform and ethanol and repeated separation of the ethanolic extract on Diaion HP20 column gave the two c)rtotoxic fractions, namely the methanolic and ethyl acetate fractions. The methanolic fraction was found to contain an active glycosphingolipid, named 1-beta-O-D-glucopyranosyl-2-(2'-hydroxy-6'-ene-cosamide)-sphingosine. The glycosphingolipid exerted a cytotoxicity effect (EDroof l6 micro/ml) against human colon carcinoma (SW 620) and human breast cancer ATCC HTB20 (BT 474) cell lines.
dc.description.sponsorshipNRCT-JSPS fellowships
dc.format.extent509 KBen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationThai Journal of Phytopharmacy. 1998; Vol.5, No.1 (1998), 10-20.
dc.identifier.issn0858-9399en
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/62113
dc.language.isoengen
dc.rightsMahidol Universityen
dc.rights.holderFaculty of Pharmacy Mahidol University
dc.sourceThai Journal of Phytopharmacyen
dc.subjectMurdannia loriformisen
dc.subjectGlycosphingolipiden
dc.subjectCytotoxinsen
dc.subjectAnticanceren
dc.subjectหญ้าปักกิ่งen
dc.titleCytotoxic glycosphingolipid from Murdannia loriformis (Hassk.) Rolla Rao et Kammathyen
dc.typeResearch Articleen
dspace.entity.typePublication

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