Publication: Angiotensin Converting Enzyme Gene Polymorphism in Healthy Thais and Patients with Non-Insulin Dependent Diabetes Mellitus
1
Issued Date
1997-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-2442693295
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.80, No.12 (1997)
Suggested Citation
Wannee Nitiyanant, Sutin Sriussadaporn, Sirirat Ploybutr, Praneet Watanakejorn, Monchaya Tunlakit, Sasitorn Bejrachandra Angiotensin Converting Enzyme Gene Polymorphism in Healthy Thais and Patients with Non-Insulin Dependent Diabetes Mellitus. Journal of the Medical Association of Thailand. Vol.80, No.12 (1997). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18178
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Angiotensin Converting Enzyme Gene Polymorphism in Healthy Thais and Patients with Non-Insulin Dependent Diabetes Mellitus
Other Contributor(s)
Abstract
Insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene has been shown to be associated with various cardiovascular disorders in diabetic and non-diabetic patients. Its association with the development of non-insulin dependent diabetes mellitus (NIDDM) has been raised. This study was aimed to examine I/D polymorphism of ACE gene in healthy Thai subjects and patients with NIDDM. The I/D ACE genotypes were determined by polymerase chain reaction technique. Healthy unrelated subjects were 151 males and 147 females, 17-70 year old (mean±SD = 37.5±10.4). The unrelated diabetic patients were 42 males and 66 females, 20-79 years of age (mean±SD = 54.7±12.0). In healthy subjects, the ACE genotypes were DD 10.1 per cent, ID 39.2 per cent and II 50.7 per cent. Diabetic patients had similar distribution of ACE genotypes. The frequency of I and D alleles in diabetic patients was 0.69 and 0.31, similar to 0.70 and 0.30, respectively, in healthy subjects (p = 0.69). The frequency of I and D alleles in healthy Thai subjects was similar to the Japanese (I = 0.66 & D = 0.34) but different from Caucasians (I = 0.44-0.46 & D = 0.54-0.56). We conclude that I/D ACE gene polymorphisms may possess a racial difference. The similar frequency of both alleles in diabetic patients and healthy subjects suggests that there is no association between I/D polymorphism of ACE gene and diabetes mellitus in Thai individuals.