Publication: Quinine toxicity when given with doxycycline and mefloquine.
Issued Date
1994-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0028459336
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.25, No.2 (1994), 397-400
Suggested Citation
J. Karbwang, K. N. Bangchang, A. Thanavibul, Y. Wattanakoon, T. Harinasuta Quinine toxicity when given with doxycycline and mefloquine.. The Southeast Asian journal of tropical medicine and public health. Vol.25, No.2 (1994), 397-400. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9664
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Title
Quinine toxicity when given with doxycycline and mefloquine.
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Abstract
The pharmacokinetic and dynamic interactions among 3 antimalarials, ie quinine, doxycycline and mefloquine was observed in a 26-year-old Thai male patient with falciparum malaria. During the acute episode of the infection, the patient was treated with an intravenous dose of quinine hydrochloride at 600 mg qid, together with an oral dose of doxycycline 100 mg bid. Due to nausea, tinnitus and the persistence of parasitemia in peripheral blood smears, the dose of quinine was reduced 2 days after the first treatment to 300 mg; concurrently oral mefloquine 750 mg was given as 2 divided doses at 24 hours apart. During the course of treatment, the patient developed hearing loss; deafness of the right ear lasted for one week after stopping quinine administration. Higher plasma quinine and lower whole blood mefloquine concentrations than would be expected from the simulation profiles were detected 4 days after the first treatment. However, the concentration of mefloquine was increased upon the cessation of quinine treatment.