Publication: Effect of charged and non-ionic membrane additives on physicochemical properties and stability of niosomes
3
Issued Date
2008-07-18
Resource Type
ISSN
15309932
Other identifier(s)
2-s2.0-57149135635
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
AAPS PharmSciTech. Vol.9, No.3 (2008), 851-859
Suggested Citation
Varaporn Buraphacheep Junyaprasert, Veerawat Teeranachaideekul, Tasaneeya Supaperm Effect of charged and non-ionic membrane additives on physicochemical properties and stability of niosomes. AAPS PharmSciTech. Vol.9, No.3 (2008), 851-859. doi:10.1208/s12249-008-9121-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19866
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effect of charged and non-ionic membrane additives on physicochemical properties and stability of niosomes
Other Contributor(s)
Abstract
The aim of this study was to investigate an influence of different types of membrane additives including negative charge (dicetylphosphate, DCP), positive charge (stearylamine, STR) and non-ionic molecule (cholesteryl poly-24-oxyethylene ether, SC24) on the physicochemical properties of drug-free and drug-loaded niosomes. Salicylic acid having different proportions of ionized and unionized species at different pH was selected as a model drug. The niosomes were composed of 1:1 mole ratio of Span 60: cholesterol as vesicle forming agents. The results show that incorporation of salicylic acid to the niosomes did not affect zeta potential values; however, addition of the membrane additives changed the zeta potential depending on the type of the additives. Transmission electron microscopy revealed that niosomes had unilamellar structure. The particle sizes of all developed niosomes were between 217 to 360 nm. The entrapment efficiency (%E.E.) of all salicylic acid niosomes at pH 3 was higher than that of niosomes at pH 5, indicating that salicylic acid in unionized form was preferably incorporated in niosomes. Furthermore, the positively charged niosomes showed the highest %E.E. of salicylic acid owing to electrostatic attraction between STR and salicylic acid. After 3 months of storage at 4°C, the particle size of the niosomes remained in the nanosize range except for DCP salicylic acid niosomes at pH 3 whose size increased due to an instability of DCP at low pH. In addition, all niosomes showed no leakage of the salicylic acid after 3 months of storage indicating the good stability. © American Association of Pharmaceutical Scientists 2008.