Publication:
Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1

dc.contributor.authorChao Chieh Hsiehen_US
dc.contributor.authorChiung Yun Changen_US
dc.contributor.authorTania Xu Yar Leeen_US
dc.contributor.authorJinfu Wuen_US
dc.contributor.authorSuchada Saoviengen_US
dc.contributor.authorYu Wen Hsiehen_US
dc.contributor.authorMaijian Zhuen_US
dc.contributor.authorChih Yang Huangen_US
dc.contributor.authorChia Hua Kuoen_US
dc.contributor.otherTzu Chi University of Science and Technologyen_US
dc.contributor.otherUniversity of Taipeien_US
dc.contributor.otherAsia Universityen_US
dc.contributor.otherChina Medical University Hospitalen_US
dc.contributor.otherBuddhist Tzu-Chi General Hospital Taiwanen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChina Medical Universityen_US
dc.contributor.otherSouth China Normal Universityen_US
dc.date.accessioned2022-08-04T08:14:35Z
dc.date.available2022-08-04T08:14:35Z
dc.date.issued2021-01-01en_US
dc.description.abstractBackground: Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. Purpose: To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1. Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results: No significant differences in longevity (control: 706 days; Rg1: 651 days, p = 0.77) and tumor incidence (control: 19%; Rg1: 12%, p = 0.24) were observed between the two groups. Movement distance in the control group declined significantly by ∼60% at 21 months of age, together with decreased TNF-α (p = 0.01) and increased IL-10 (p = 0.02). However, the movement distance in the Rg1 group was maintained ∼50% above the control groups (p = 0.01) at 21 months of age with greater magnitudes of TNF-α decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period. Conclusion: The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.en_US
dc.identifier.citationJournal of Ginseng Research. (2021)en_US
dc.identifier.doi10.1016/j.jgr.2021.04.006en_US
dc.identifier.issn12268453en_US
dc.identifier.other2-s2.0-85104992698en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/76381
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85104992698&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleLongevity, tumor, and physical vitality in rats consuming ginsenoside Rg1en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85104992698&origin=inwarden_US

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