Publication: Chikungunya and zika viruses: Co-circulation and the interplay between viral proteins and host factors
Issued Date
2021-04-01
Resource Type
ISSN
20760817
Other identifier(s)
2-s2.0-85104535998
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pathogens. Vol.10, No.4 (2021)
Suggested Citation
Sineewanlaya Wichit, Nuttamonpat Gumpangseth, Rodolphe Hamel, Sakda Yainoy, Siwaret Arikit, Chuchard Punsawad, Dorothée Missé Chikungunya and zika viruses: Co-circulation and the interplay between viral proteins and host factors. Pathogens. Vol.10, No.4 (2021). doi:10.3390/pathogens10040448 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76222
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Chikungunya and zika viruses: Co-circulation and the interplay between viral proteins and host factors
Abstract
Chikungunya and Zika viruses, both transmitted by mosquito vectors, have globally re-emerged over for the last 60 years and resulted in crucial social and economic concerns. Presently, there is no specific antiviral agent or vaccine against these debilitating viruses. Understanding viral- host interactions is needed to develop targeted therapeutics. However, there is presently limited information in this area. In this review, we start with the updated virology and replication cycle of each virus. Transmission by similar mosquito vectors, frequent co-circulation, and occurrence of co-infection are summarized. Finally, the targeted host proteins/factors used by the viruses are discussed. There is an urgent need to better understand the virus-host interactions that will facilitate antiviral drug development and thus reduce the global burden of infections caused by arboviruses.