Publication: The involvement of microglial cells in japanese encephalitis infections
Issued Date
2012-09-18
Resource Type
ISSN
17402530
17402522
17402522
Other identifier(s)
2-s2.0-84866166958
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Developmental Immunology. Vol.2012, (2012)
Suggested Citation
Thananya Thongtan, Chutima Thepparit, Duncan R. Smith The involvement of microglial cells in japanese encephalitis infections. Clinical and Developmental Immunology. Vol.2012, (2012). doi:10.1155/2012/890586 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14265
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Title
The involvement of microglial cells in japanese encephalitis infections
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Abstract
Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30 of JE cases admitted to hospital die and 50 of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection. © 2012 Thananya Thongtan et al.