Publication:
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns

Simple item page
dc.contributor.authorAmol C. Shettyen_US
dc.contributor.authorChristopher G. Jacoben_US
dc.contributor.authorFang Huangen_US
dc.contributor.authorYao Lien_US
dc.contributor.authorSonia Agrawalen_US
dc.contributor.authorDavid L. Saundersen_US
dc.contributor.authorChanthap Lonen_US
dc.contributor.authorMark M. Fukudaen_US
dc.contributor.authorPascal Ringwalden_US
dc.contributor.authorElizabeth A. Ashleyen_US
dc.contributor.authorKay Thwe Hanen_US
dc.contributor.authorTin Maung Hlaingen_US
dc.contributor.authorMyaing M. Nyunten_US
dc.contributor.authorJoana C. Silvaen_US
dc.contributor.authorKathleen E. Stewarten_US
dc.contributor.authorChristopher V. Ploween_US
dc.contributor.authorTimothy D. O’Connoren_US
dc.contributor.authorShannon Takala-Harrisonen_US
dc.contributor.authorHarald Noedlen_US
dc.contributor.authorWasif A. Khanen_US
dc.contributor.authorPaul Newtonen_US
dc.contributor.authorMyat P. Kyawen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.authorNicholas P. Dayen_US
dc.contributor.authorCharles J. Woodrowen_US
dc.contributor.authorMehul Dhordaen_US
dc.contributor.authorM. Abul Faizen_US
dc.contributor.authorRick M. Fairhursten_US
dc.contributor.authorPharath Limen_US
dc.contributor.authorRupam Tripuraen_US
dc.contributor.authorMayfong Mayxayen_US
dc.contributor.authorYe Htuten_US
dc.contributor.authorFrancois Nostenen_US
dc.contributor.authorAung Pyae Phyoen_US
dc.contributor.authorSasithon Pukrittayakameeen_US
dc.contributor.authorTran Tinh Hienen_US
dc.contributor.authorNguyen Thanh Thuy Nhienen_US
dc.contributor.authorOlugbenga A. Mokuoluen_US
dc.contributor.authorCaterina I. Fanelloen_US
dc.contributor.authorMarie A. Onyambokoen_US
dc.contributor.otherMedizinische Universitat Wien, Zentrum für Pathophysiologie, Infektiologie und Immunologieen_US
dc.contributor.otherChinese Center for Disease Control and Preventionen_US
dc.contributor.otherOrganisation Mondiale de la Santéen_US
dc.contributor.otherUniversity of Marylanden_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherUniversity of Maryland School of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Ilorinen_US
dc.contributor.otherInternational Centre for Diarrhoeal Disease Research Bangladeshen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherDuke Universityen_US
dc.contributor.otherWellcome Sanger Instituteen_US
dc.contributor.otherUniversity of Health Sciencesen_US
dc.contributor.otherMalaria Research Group and Dev Care Foundationen_US
dc.contributor.otherLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)en_US
dc.contributor.otherDefence Services Medical Research Centreen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciencesen_US
dc.contributor.otherWorldWide Antimalarial Resistance Networken_US
dc.contributor.otherOxford University Clinical Research Unit (OUCRU)en_US
dc.contributor.otherMinistry of Healthen_US
dc.date.accessioned2020-01-27T07:35:38Z
dc.date.available2020-01-27T07:35:38Z
dc.date.issued2019-12-01en_US
dc.description.abstract© 2019, The Author(s). Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.en_US
dc.identifier.citationNature Communications. Vol.10, No.1 (2019)en_US
dc.identifier.doi10.1038/s41467-019-10121-3en_US
dc.identifier.issn20411723en_US
dc.identifier.other2-s2.0-85067602013en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/50027
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067602013&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.titleGenomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patternsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067602013&origin=inwarden_US

Files

Collections

Scopus 2019