Publication: Ethanolic Fruit Extract of Emblica officinalis Suppresses Neuroinflammation in Microglia and Promotes Neurite Outgrowth in Neuro2a Cells
Issued Date
2021-01-01
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ISSN
17414288
1741427X
1741427X
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2-s2.0-85115738835
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Mahidol University
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SCOPUS
Bibliographic Citation
Evidence-based Complementary and Alternative Medicine. Vol.2021, (2021)
Suggested Citation
Sataporn Phochantachinda, Duangthip Chatchaisak, Piya Temviriyanukul, Anchana Chansawang, Pornsiri Pitchakarn, Boonrat Chantong Ethanolic Fruit Extract of Emblica officinalis Suppresses Neuroinflammation in Microglia and Promotes Neurite Outgrowth in Neuro2a Cells. Evidence-based Complementary and Alternative Medicine. Vol.2021, (2021). doi:10.1155/2021/6405987 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78608
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Title
Ethanolic Fruit Extract of Emblica officinalis Suppresses Neuroinflammation in Microglia and Promotes Neurite Outgrowth in Neuro2a Cells
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Abstract
Inhibiting neuroinflammation and modulating neurite outgrowth could be a promising strategy to prevent neurological disorders. Emblica officinalis (EO) may be a potent agent against them. Although EO extract reportedly has anti-inflammatory properties in macrophages, there is limited knowledge about its neuroprotective activity by suppressing microglia-mediated proinflammatory cytokine production and inducing neurite outgrowth. The present study aimed to elucidate the effect of EO fruit extract on the lipopolysaccharide- (LPS-) induced neuroinflammation using microglial (BV2) and neuroblastoma (Neuro2a) cells. The results demonstrated that, in LPS-treated BV2 cells, EO fruit extract reduced nitric oxide, interleukin-6, and tumor necrotic factor-α production. It also enhanced the neurite length of Neuro2a cells, which was linked to the upregulation of TuJ1 and MAP2 expressions. In conclusion, these findings indicate that the ethanolic extract of EO fruits has promising neuroprotective potential to exhibit antineuroinflammation activity and accelerative effect on neurite outgrowth in vitro. Therefore, EO fruit extract can be considered a novel herbal medicine candidate for managing neuroinflammatory diseases.