Publication: Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 ( pvmdr1) polymorphisms
Issued Date
2013-06-01
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ISSN
00029637
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2-s2.0-84878603905
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.88, No.6 (2013), 1116-1123
Suggested Citation
Jessica T. Lin, Jaymin C. Patel, Oksana Kharabora, Jetsumon Sattabongkot, Sinuon Muth, Ratawan Ubalee, Anthony L. Schuster, William O. Rogers, Chansuda Wongsrichanalai, Jonathan J. Juliano Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 ( pvmdr1) polymorphisms. American Journal of Tropical Medicine and Hygiene. Vol.88, No.6 (2013), 1116-1123. doi:10.4269/ajtmh.12-0701 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31916
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Title
Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 ( pvmdr1) polymorphisms
Abstract
Plasmodium vivax accounts for an increasing fraction of malaria infections in Thailand and Cambodia. We compared P. vivax genetic complexity and antimalarial resistance patterns in the two countries. Use of a heteroduplex tracking assay targeting the merozoite surface protein 1 gene revealed that vivax infections in both countries are frequently polyclonal (84%), with parasites that are highly diverse (HE = 0.86) but closely related (GST = 0.18). Following a history of different drug policies in Thailand and Cambodia, distinct patterns of antimalarial resistance have emerged: most Cambodian isolates harbor the P. vivax multidrug resistance gene 1 (pvmdr1) 976F mutation associated with chloroquine resistance (89% versus 8%, P < 0.001), whereas Thai isolates more often display increased pvmdr1 copy number (39% versus 4%, P < 0.001). Finally, genotyping of paired isolates from individuals suspected of suffering relapse supports a complex scheme of relapse whereby recurrence of multiple identical variants is sometimes accompanied by the appearance of novel variants. Copyright © 2013 by The American Society of Tropical Medicine and Hygiene.