Publication: Antimicrobial resistance among Clostridium perfringens isolated from various sources in Thailand
Issued Date
2005-07-01
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ISSN
01251562
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2-s2.0-27744530126
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.4 (2005), 954-961
Suggested Citation
Unchalee Tansuphasiri, Wiriya Matra, Leelaowadee Sangsuk Antimicrobial resistance among Clostridium perfringens isolated from various sources in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.4 (2005), 954-961. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16934
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Title
Antimicrobial resistance among Clostridium perfringens isolated from various sources in Thailand
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Abstract
Antimicrobial resistance among Clostridium perfringens isolated from feces of humans and pigs, food and other environmental sources was examined by testing of 201 PCR-confirmed strains for resistance to 7 antimicrobial agents. The minimal inhibitory concentrations (MICs) were determined by the agar dilution method. Overall, C. perfringens showed the highest resistance to tetracycline (56.2%), followed by imipenem (24.9%), metronidazole (9.5%), penicillin G (9%), vancomycin (4.5%), chloramphenicol (3%) and ceftriaxone (1%). The majority of the isolated strains from pig feces (77.8%), environment (72.7%), human feces (44.9%) and food (28%) showed resistance to tetracycline. Strains isolated from human feces only showed low resistance to ceftriaxone (2.5%) and vancomycin (10.1%). Penicillin G had high activity, with overall MIC50 and MIC90 of 0.06 and 1.0 μg/ml, respectively, and low rate of resistance (10-12% for strains isolated from humans, animals and food). Among 62.7% of antimicrobial resistant strains, 39.3% were resistant to a single drug and 23.4% were multiple-drug resistant (MDR). Of overall 47 MDR strains, 63.8% were derived from human feces and were resistant to two to six drugs.