Publication:
α,α-Difluoro-α-phenylsulfanyl-α- trimethylsilylmethane as a difluoromethyl building block: A general strategy to α,α-difluoromethyl aryl ketones

1

Issued Date

2011-11-01

Resource Type

Article

ISSN

00221139

DOI

10.1016/j.jfluchem.2011.06.036

Other identifier(s)

2-s2.0-80052723325

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

Journal of Fluorine Chemistry. Vol.132, No.11 (2011), 987-990

Suggested Citation

Kanhokthron Boonkitpattarakul, Darunee Soorukram, Patoomratana Tuchinda, Vichai Reutrakul, Manat Pohmakotr α,α-Difluoro-α-phenylsulfanyl-α- trimethylsilylmethane as a difluoromethyl building block: A general strategy to α,α-difluoromethyl aryl ketones. Journal of Fluorine Chemistry. Vol.132, No.11 (2011), 987-990. doi:10.1016/j.jfluchem.2011.06.036 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11437

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Title

α,α-Difluoro-α-phenylsulfanyl-α- trimethylsilylmethane as a difluoromethyl building block: A general strategy to α,α-difluoromethyl aryl ketones

Author(s)

Kanhokthron Boonkitpattarakul
 Darunee Soorukram
 Patoomratana Tuchinda
 Vichai Reutrakul
 Manat Pohmakotr

Other Contributor(s)

Mahidol University

Abstract

The synthetic utility of α,α-difluoro-α-phenylsulfanyl- α-trimethylsilylmethane (PhSCF 2 SiMe 3 ; 1) as a difluoromethyl building block providing a general strategy to α,α-difluoromethyl aryl ketones was demonstrated. Oxidation, by using m-chloroperoxybenzoic acid, of the readily available 1-aryl-2,2-difluoro- 2-phenylsulfanyl-1-trimethylsiloxyethanes obtained from fluoride-catalyzed nucleophilic addition of PhSCF 2 SiMe 3 with aromatic aldehydes followed by flash vacuum pyrolytic elimination provided α,α-difluoromethyl aryl ketones in moderate overall yields. © 2011 Published by Elsevier B.V. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Environmental Science

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/11437

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Scopus 2011-2015