Publication: T cell responses in acute falciparum malaria
Issued Date
1990-01-01
Resource Type
ISSN
01652478
Other identifier(s)
2-s2.0-0025150827
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Mahidol University
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SCOPUS
Bibliographic Citation
Immunology Letters. Vol.25, No.1-3 (1990), 135-138
Suggested Citation
May Ho, H. Kyle Webster T cell responses in acute falciparum malaria. Immunology Letters. Vol.25, No.1-3 (1990), 135-138. doi:10.1016/0165-2478(90)90104-X Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15968
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Title
T cell responses in acute falciparum malaria
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Abstract
T lymphocyte responses to malaria-specific antigens during acute falciparum malaria were studied to determine host-parasite interaction and its relation to the manifestations of the disease. The results indicate that while there is antigen-specific immunodepression, markedly elevated levels of soluble factors such as IL 2 receptor, CD8 antigen and IFN-γ suggest that there is intense concurrent cellular activation which however does not seem to be effective in controlling the infection. It is proposed that the cellular activation is to a large extent non-specific and polyclonal, and leads to the exaggerated production of cytokines and eventually immunopathology. Various mechanisms of immunodepression are discussed. © 1990.