Publication: Approximate solutions and parameter estimations of G-protein coupled receptor signal transduction model
Issued Date
2013-02-20
Resource Type
ISSN
09720871
Other identifier(s)
2-s2.0-84873919912
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Far East Journal of Mathematical Sciences. Vol.73, No.SPL. (2013), 21-39
Suggested Citation
Charin Modchang, Busayamas Pimpunchat, Yongwimon Lenbury, Wannapong Triampo Approximate solutions and parameter estimations of G-protein coupled receptor signal transduction model. Far East Journal of Mathematical Sciences. Vol.73, No.SPL. (2013), 21-39. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32027
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Title
Approximate solutions and parameter estimations of G-protein coupled receptor signal transduction model
Abstract
We find approximate analytical solutions of a model for the signal transduction mediated by the G-protein coupled receptor proposed earlier by Modchang et al. The time evolution of the approximate solutions will be explored and compared with numerical solutions of the model. Moreover, an alternative procedure for estimating unknown parameters in the model has been proposed. This alternative parameter estimation method directly uses the exact equilibrium solutions for fitting with the experimental data. We found that this new parameter estimation method can estimate unknown parameter values faster than the method used in previous works. © 2013 Pushpa Publishing House.