Publication: The first plasmodium vivax relapses of life are usually genetically homologous
Issued Date
2012-02-15
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00221899
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2-s2.0-84856249714
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.205, No.4 (2012), 680-683
Suggested Citation
Mallika Imwong, Mac Hteld E Boel, Watcharee Pagornrat, Mupawjay Pimanpanarak, Rose McGready, Nicholas P J Day, Franois Nosten, Nicholas J. White The first plasmodium vivax relapses of life are usually genetically homologous. Journal of Infectious Diseases. Vol.205, No.4 (2012), 680-683. doi:10.1093/infdis/jir806 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14949
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Title
The first plasmodium vivax relapses of life are usually genetically homologous
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Abstract
In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to the initial infection in 13 of 20 (65%) mothers compared with 5 of 24 (21%) infants (P =. 02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations. © 2011 The Author.