Publication: Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer
6
Issued Date
2001-03-01
Resource Type
ISSN
01251562
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2-s2.0-0035292351
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.1 (2001), 208-215
Suggested Citation
Chaweewan Prucksunand, Bunjob Indrasukhsri, Manit Leethochawalit, Korpong Hungspreugs Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.1 (2001), 208-215. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26837
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Title
Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer
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Abstract
The study examined patients who had symptoms indicating peptic ulcer. Forty-five patients, 24 males and 21 females, aged between 16-60 years were included in the study. Twenty-five patients, 18 males and 7 females, were endoscoped, their ulcers located in the duodenal bulb and gastric (angulus). The ulcer sizes varied between 0.5 to 1.5 cm in diameter. Capsule-filled turmeric was given orally in the dose of 2 capsules (300 mg each) five times daily, one half to an hour before meals, at 16.00 hours and at bedtime continuously. The result after 4 weeks of treatment showed that ulcers were absent in 48% or 12 cases (DU 9 and GU 3). Eighteen cases (DU 13 and GU 5) had absence of ulcer after 8 weeks of treatment. Nineteen cases (76%) (DU 14 and GU 5) did not have ulcers after 12 weeks of treatment. The rest, 20 cases were not found to have ulcers and some were not endoscoped. They appeared to have erosions, gastritis and dyspepsia. They received turmeric capsules for 4 weeks of treatment. The abdominal pain and discomfort satisfactorily subsided in the first and second week. They could take normal foods instead of soft meals. Blood chemistry and hematology of all 54 patients had no significant changes in hematological system, liver and renal functions both before and after treatment.