Publication: Measles vaccination of Thai infants by intranasal and subcutaneous routes: Possible interference from respiratory infections
1
Issued Date
1997-01-01
Resource Type
ISSN
0264410X
Other identifier(s)
2-s2.0-0030997950
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Vaccine. Vol.15, No.3 (1997), 329-334
Suggested Citation
S. Simasathien, S. Migasena, W. Bellini, R. Samakoses, P. Pitisuttitham, W. Bupodom, J. Heath, L. Anderson, J. Bennett Measles vaccination of Thai infants by intranasal and subcutaneous routes: Possible interference from respiratory infections. Vaccine. Vol.15, No.3 (1997), 329-334. doi:10.1016/S0264-410X(97)00104-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17927
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Title
Measles vaccination of Thai infants by intranasal and subcutaneous routes: Possible interference from respiratory infections
Abstract
Reactogenicity and seroresponses were studied after standard doses of Edmonston-Zagreb measles vaccine were given intranasally (i.n.) and subcutaneously (s.c.) to 6-month-old Thai children. Few children given i.n. vaccine (2/31), but most (13/21) given s.c. vaccine, seroconverted. All but 1 of 51 children were seropositive after receiving vaccine s.c. at 9 months-of-age. Upper respiratory infection (URI) outbreaks with onsets in the week following vaccination occurred after each vaccination session and were equally common in all groups. URIs following i.n. vaccination at 6 months may have adversely affected response to i.n. vaccine, while URIs after s.c. vaccination at 9 months adversely affected final geometric mean antibody titers. I.n. measles vaccination does not appear to be an acceptable route for routine vaccination.