Publication: Superantigens
Issued Date
2010-06-01
Resource Type
ISSN
00306665
Other identifier(s)
2-s2.0-77953525403
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Mahidol University
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SCOPUS
Bibliographic Citation
Otolaryngologic Clinics of North America. Vol.43, No.3 (2010), 489-502
Suggested Citation
Nicholas W. Stow, Richard Douglas, Pongsakorn Tantilipikorn, Jean Silvain Lacroix Superantigens. Otolaryngologic Clinics of North America. Vol.43, No.3 (2010), 489-502. doi:10.1016/j.otc.2010.02.008 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29648
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Title
Superantigens
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Abstract
Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance. They can also act as superallergens by stimulating a broad spectrum of mast cells and basophils in patients with allergic conditions. The newly described staphylococcal SAg-like proteins subvert innate immune function by several mechanisms, which are distinct from SAgs' effects on lymphocytes and other acquired immune processes. There is mounting evidence to suggest that SAgs play a role in the pathophysiology of inflammatory airway disease. The pathophysiologic role of SAg-like proteins awaits clarification. © 2010 Elsevier Inc.