Publication: Trehalose and bacterial virulence
Issued Date
2020-01-01
Resource Type
ISSN
21505608
21505594
21505594
Other identifier(s)
2-s2.0-85089974672
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Virulence. Vol.11, No.1 (2020), 1192-1202
Suggested Citation
Muthita Vanaporn, Richard W. Titball Trehalose and bacterial virulence. Virulence. Vol.11, No.1 (2020), 1192-1202. doi:10.1080/21505594.2020.1809326 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59127
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Trehalose and bacterial virulence
Author(s)
Other Contributor(s)
Abstract
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage, which plays both structural and functional roles in bacteria. Trehalose can be synthesized and degraded by several pathways, and induction of trehalose biosynthesis is typically associated with exposure to abiotic stress. The ability of trehalose to protect against abiotic stress has been exploited to stabilize a range of bacterial vaccines. More recently, there has been interest in the role of this molecule in microbial virulence. There is now evidence that trehalose or trehalose derivatives play important roles in virulence of a diverse range of Gram-positive and Gram-negative pathogens of animals or plants. Trehalose and/or trehalose derivatives can play important roles in host colonization and growth in the host, and can modulate the interactions with host defense mechanisms. However, the roles are typically pathogen-specific. These findings suggest that trehalose metabolism may be a target for novel pathogen-specific rather than broad spectrum interventions.