Publication: Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand
Issued Date
2000-12-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-0034437727
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.63, No.5-6 (2000), 290-294
Suggested Citation
P. Wilairatna, S. Krudsood, U. Silachamroon, P. Singhasivanon, S. Vannaphan, S. Faithong, M. Klabprasit, S. Na Bangchang, P. Olliaro, S. Looareesuwan Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand. American Journal of Tropical Medicine and Hygiene. Vol.63, No.5-6 (2000), 290-294. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25958
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand
Other Contributor(s)
Abstract
One hundred and fifty patients with severe falciparum malaria were administered sequential combination of dihydroartemisinin suppository followed by an oral mefloquine tablet. Dihydroartemisinin suppositories (80 mg/ capsule) were given rectally once daily for 3 days with a total dose of 8-10 mg/kg. Two doses of mefloquine, 15 mg/kg/dose and 10 mg/kg/dose, were given at 72 hr and 84 hr, respectively. The mean [SD] parasite clearance time and fever clearance time were 46.1 [15.7] hr and 82.5 [59.6] hr, respectively. No death or major adverse drug effects occurred. The cure rate at 28 days of inpatient follow-up was 95% (113 of 119 patients). In severe malaria, dihydroartemisinin suppository followed by oral mefloquine is a suitable alternative treatment to parenteral drugs.