Publication: HIGH RATE OF PLASMODIUM VIVAX RELAPSE FOLLOWING TREATMENT OF FALCIPARUM MALARIA IN THAILAND
Issued Date
1987-11-07
Resource Type
ISSN
01406736
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2-s2.0-0023242493
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Mahidol University
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SCOPUS
Bibliographic Citation
The Lancet. Vol.330, No.8567 (1987), 1052-1055
Suggested Citation
Sornchai Looareesuwan, Nicholas J. White, Danai Bunnag, Sunee Chittamas, Tranakchit Harinasuta HIGH RATE OF PLASMODIUM VIVAX RELAPSE FOLLOWING TREATMENT OF FALCIPARUM MALARIA IN THAILAND. The Lancet. Vol.330, No.8567 (1987), 1052-1055. doi:10.1016/S0140-6736(87)91479-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15400
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Title
HIGH RATE OF PLASMODIUM VIVAX RELAPSE FOLLOWING TREATMENT OF FALCIPARUM MALARIA IN THAILAND
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Abstract
Within two months of treatment for falciparum malaria, Plasmodium vivaxinfections developed in 58 (33%) of 174 patients who had received a quinine or quinidine regimen and in 46 (32%) of 145 patients who had received mefloquine with inpatient follow-up of more than six weeks. The time to vivax relapse was significantly longer after mefloquine treatment (median 47 days, range 30-65) than after quinine or quinidine treatment (21 days, 15-36; p < 0·0001). All patients remained outside areas of malaria transmission. These findings suggest a very high rate of double infection in Thailand with acute suppression of vivax by falciparum malaria, and warrant evaluation of radical therapy with primaquine in certain patients with acute falciparum malaria. © 1987.