Publication: Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways
Issued Date
2014-09-22
Resource Type
ISSN
14220067
16616596
16616596
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2-s2.0-84907882606
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.15, No.9 (2014), 16848-16884
Suggested Citation
Anorut Jenwitheesuk, Chutikorn Nopparat, Sujira Mukda, Prapimpun Wongchitrat, Piyarat Govitrapong Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. International Journal of Molecular Sciences. Vol.15, No.9 (2014), 16848-16884. doi:10.3390/ijms150916848 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33223
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Title
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways
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Abstract
© 2014 by the authors; licensee MDPI, Basel, Switzerland. Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.