Publication: Clinical indicators for pulmonary arterial hypertension in thalassemia
Issued Date
2012-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-84856870900
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.95, No.1 (2012), 16-21
Suggested Citation
Nonlawan Chueamuangphan, Wattana Wongtheptien, Weerasak Nawarawong, Apichard Sukornthasarn, Suporn Chuncharunee, Chamaiporn Tawichasri, Jayanton Patumanond Clinical indicators for pulmonary arterial hypertension in thalassemia. Journal of the Medical Association of Thailand. Vol.95, No.1 (2012), 16-21. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15097
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Clinical indicators for pulmonary arterial hypertension in thalassemia
Other Contributor(s)
Abstract
Objective: To explore clinical indicators for pulmonary arterial hypertension (PAH) in thalassemia (Thal). Material and Method: A study was conducted in thalassemia patients at Chiang Rai Hospital, Chiang Rai, Thailand. Pulmonary artery systolic pressure (PASP) was determined by doppler echocardiography and PAH was defined as PASP > 35 mmHg. Patient characteristics were extracted from medical records. Characteristics of patients with and without PAH were compared. Risk indicators were explored with logistic regression analysis. Results: Two hundred twenty four patients were included, 144 E/β-Thal, 37 homozygous β-Thal and 43 Hb H disease. There were 65 patients (29.0%) with PAH, 53 (81.5%) with E/β-Thal, 8 (12.3%) with homozygous β-Thal and 4 (6.2%) with Hb H disease. In a multivariable analysis, features significantly associated with PAH were E/β-Thal (OR = 1.98, 95% CI; 1.29-3.01) and post splenectomy status (OR = 2.36, 95% CI; 1.17-4.73). Conclusion: Significant indicators for PAH in thalassemia were E/β-Thal and post splenectomy status.