Publication: Anti-inflammatory activity of compound D {(E)-4-(3',4'-dimethoxyphenyl)but-3-en-2-ol} isolated from Zingiber cassumunar Roxb.
Issued Date
1997-01-01
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ISSN
09447113
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2-s2.0-3843099390
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytomedicine. Vol.4, No.3 (1997), 207-212
Suggested Citation
A. Panthong, D. Kanjanapothi, W. Niwatananant, P. Tuntiwachwuttikul, V. Reutrakul Anti-inflammatory activity of compound D {(E)-4-(3',4'-dimethoxyphenyl)but-3-en-2-ol} isolated from Zingiber cassumunar Roxb.. Phytomedicine. Vol.4, No.3 (1997), 207-212. doi:10.1016/S0944-7113(97)80069-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17923
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Title
Anti-inflammatory activity of compound D {(E)-4-(3',4'-dimethoxyphenyl)but-3-en-2-ol} isolated from Zingiber cassumunar Roxb.
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Abstract
Compound D, (E)-4-(3',4'-dimethoxyphenyl)but-3-en-2-ol, is one of many compounds found in the hexane extract of Zingiber cassumunar Roxb. The anti-inflammatory activity of compound D was assessed using various inflammatory models in comparison with aspirin, indomethacin and prednisolone. The results obtained showed that the anti-inflammatory effect of compound D mediated prominently on the acute phase of inflammation. It exerted marked inhibition on carrageenin-induced rat paw edema as well as on the exudate formation, leukocyte accumulation and prostaglandin biosynthesis in carrageenin-induced rat pleurisy. Compound D possessed only slight inhibition on both primary and secondary lesions of adjuvant-induced arthritis and had no effect on cotton pellet-induced granuloma. Compound D elicited analgesic activity when tested on acetic acid-induced writhing response in mice but had weak inhibitory activity on tail flick responding to radiant heat. Compound D possessed marked antipyretic effect when tested on yeast-induced hyperthermia in rats.