Publication: Layer-by-layer nanocoating of antibacterial niosome on orthopedic implant
Issued Date
2018-08-25
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ISSN
18733476
03785173
03785173
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2-s2.0-85048471014
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics. Vol.547, No.1-2 (2018), 235-243
Suggested Citation
Anupma Dwivedi, Anisha Mazumder, Norased Nasongkla Layer-by-layer nanocoating of antibacterial niosome on orthopedic implant. International Journal of Pharmaceutics. Vol.547, No.1-2 (2018), 235-243. doi:10.1016/j.ijpharm.2018.05.075 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47301
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Title
Layer-by-layer nanocoating of antibacterial niosome on orthopedic implant
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Abstract
© 2018 Elsevier B.V. The major clinical hindrance of orthopedic implants is the bacterial infection, which can lead to biofilm formation and ultimately results in implant rejection. In this research, layer-by-layer nanocoating consists of vancomycin/PLA/vancomycin-loaded niosomes was designed. Vancomycin-loaded niosomes were formulated by thin film hydration method and the attributes of niosomes in terms of size, zeta potential, drug loading and EE, were assessed. The size was 340.5 ± 2.95 nm with the zeta potential and %EE was 45.4 ± 0.77 mV and 50.47 ± 3.66% respectively. The dip coating technique was used to deposit a thin film, which was characterized morphologically under FE-SEM. Drug release from coated bone plates with and without vancomycin-loaded niosomes was also studied and results suggested that bone plates coated with vancomycin-loaded niosomes have accumulated more vancomycin than the control group and hence aided in the prolonged release up to two weeks. These niosomes-coated bone plates demonstrated superior antibacterial activity for longer time period, without exhibiting any cytotoxic effects towards normal cells (L929). These findings offer a promising approach to control the bacterial colonization and biofilms formation. This thin film nano-coating can also be utilized in coating of other medical devices, which are prone to infections.