Publication: Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
Issued Date
2010-11-01
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ISSN
00029637
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2-s2.0-79952054938
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.83, No.5 (2010), 1066-1069
Suggested Citation
T. Eoin West, Nicolle D. Myers, Direk Limmathurotsakul, H. Denny Liggitt, Narisara Chantratita, Sharon J. Peacock, Shawn J. Skerrett Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice. American Journal of Tropical Medicine and Hygiene. Vol.83, No.5 (2010), 1066-1069. doi:10.4269/ajtmh.2010.10-0306 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29182
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Title
Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
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Abstract
Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei. Although transcutaneous inoculation and inhalation are considered the primary routes of infection, suggestive clinical evidence implicates ingestion as a possible alternative route. We show that in BALB/c and C57BL/6 mice, direct gastric inoculation of high doses of B. pseudomallei causes systemic infection that may be lethal or cause chronic disseminated infection. Mice may shed bacteria in the stool for weeks after infection, and high titers of B. pseudomallei-specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.