Publication: miRNA regulation of glucose and lipid metabolism in relation to diabetes and non-alcoholic fatty liver disease
Issued Date
2019-01-01
Resource Type
ISSN
22148019
00652598
00652598
Other identifier(s)
2-s2.0-85063965231
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Advances in Experimental Medicine and Biology. Vol.1134, (2019), 129-148
Suggested Citation
Tanapa Suksangrat, Phatchariya Phannasil, Sarawut Jitrapakdee miRNA regulation of glucose and lipid metabolism in relation to diabetes and non-alcoholic fatty liver disease. Advances in Experimental Medicine and Biology. Vol.1134, (2019), 129-148. doi:10.1007/978-3-030-12668-1_7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50300
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
miRNA regulation of glucose and lipid metabolism in relation to diabetes and non-alcoholic fatty liver disease
Other Contributor(s)
Abstract
© Springer Nature Switzerland AG 2019. Glucose and lipids are important nutrients because they provide most of the energy for the cells. A pre-translational regulation by microRNAs (miRNAs) plays a pivotal role in cellular metabolism by targeting the key rate-limiting enzymes of relevant pathways to fine-tune control of metabolic homeostasis. Aberrant expression of these miRNAs can result in an over or under expression of those key enzymes, contributing to the etiology of diabetes and non-alcoholic fatty liver disease (NAFLD). Here we discuss recent studies of various miRNAs that control insulin sensitivity, hepatic glucose production and de novo lipogenesis and how aberrant expression of these miRNAs contributes to the pathophysiology of diabetes and NAFLD in animal models. We also review the current application of circulating miRNAs as biomarkers for diagnosis or disease monitoring in diabetes and NAFLD.