Publication: Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia
Issued Date
2014-05-01
Resource Type
ISSN
10779450
15254135
15254135
Other identifier(s)
2-s2.0-84898539282
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Acquired Immune Deficiency Syndromes. Vol.66, No.1 (2014), 74-79
Suggested Citation
Praphan Phanuphak, Sunee Sirivichayakul, Awachana Jiamsakul, Somnuek Sungkanuparph, Nagalingeswaran Kumarasamy, Man Po Lee, Thira Sirisanthana, Pacharee Kantipong, Christopher Lee, Adeeba Kamarulzaman, Mahiran Mustafa, Rossana Ditangco, Tuti Merati, Winai Ratanasuwan, Thida Singtoroj, Rami Kantor Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia. Journal of Acquired Immune Deficiency Syndromes. Vol.66, No.1 (2014), 74-79. doi:10.1097/QAI.0000000000000108 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34249
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Title
Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia
Other Contributor(s)
The HIV Netherlands Australia Thailand Research Collaboration
Chulalongkorn University
University of New South Wales (UNSW) Australia
Mahidol University
YR Gaitonde Centre for AIDS Research and Education
Queen Elizabeth Hospital Hong Kong
Chiang Mai University
Chiangrai Prachanukroh Hospital
Hospital Sungai Buloh
University of Malaya
Hospital Raja Perempuan Zainab II
Gokila
Universitas Udayana
amfAR - The Foundation for AIDS Research
Brown University
Chulalongkorn University
University of New South Wales (UNSW) Australia
Mahidol University
YR Gaitonde Centre for AIDS Research and Education
Queen Elizabeth Hospital Hong Kong
Chiang Mai University
Chiangrai Prachanukroh Hospital
Hospital Sungai Buloh
University of Malaya
Hospital Raja Perempuan Zainab II
Gokila
Universitas Udayana
amfAR - The Foundation for AIDS Research
Brown University
Abstract
BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs. © 2013 by Lippincott Williams and Wilkins.