Publication: Tricyclic and spirobicyclic norsesquiterpenes from the endophytic fungus Pseudolagarobasidium acaciicola
Issued Date
2014-01-01
Resource Type
ISSN
10990690
1434193X
1434193X
Other identifier(s)
2-s2.0-84903287004
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Organic Chemistry. Vol.2014, No.19 (2014), 3976-3980
Suggested Citation
Mario Wibowo, Vilailak Prachyawarakorn, Thammarat Aree, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Tricyclic and spirobicyclic norsesquiterpenes from the endophytic fungus Pseudolagarobasidium acaciicola. European Journal of Organic Chemistry. Vol.2014, No.19 (2014), 3976-3980. doi:10.1002/ejoc.201402262 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33668
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Title
Tricyclic and spirobicyclic norsesquiterpenes from the endophytic fungus Pseudolagarobasidium acaciicola
Abstract
The new tricyclic and spirobicyclic norsesquiterpenes 1 and 2 and the new nor-chamigrane endoperoxide 3, together with the known sesquiterpenes steperoxide A (4), merulin B (5), and merulin C (6), were isolated from the endophytic fungus Pseudolagarobasidium acaciicola. The structures and absolute configurations of 1-3 were determined by analysis of spectroscopic data, as well as by single-crystal X-ray analysis. Compound 1 has a previously unobserved 6/5/5 fused tricyclic ring system, in which the five-membered (middle) ring is, as revealed by X-ray analysis, perpendicular to a six-membered ring. Compound 2 possesses a hitherto unknown 5/6 fused spirobicyclic ring system. The cytotoxic activities of the isolated compounds 1-6 were evaluated. Tricyclic and spirobicyclic norsesquiterpenes 1 and 2 were isolated from the endophytic fungus Pseudolagarobasidium acaciicola. The absolute configurations of 1 and 2 were addressed by single-crystal X-ray analysis. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.