Publication: Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon
Issued Date
2006-06-01
Resource Type
ISSN
15254135
Other identifier(s)
2-s2.0-33745092368
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Acquired Immune Deficiency Syndromes. Vol.42, No.2 (2006), 135-139
Suggested Citation
Swati B. Gupta, Christopher T. Mast, Nathan D. Wolfe, Vlad Novitsky, Sheri A. Dubey, Esper G. Kallas, Mauro Schechter, Bernard Mbewe, Eftyhia Vardas, Punee Pitisuttithum, Donald Burke, Dan Freed, Robin Mogg, Paul M. Coplan, Jon H. Condra, Romnie S. Long, Kiersten Anderson, Danilo R. Casimiro, John W. Shiver, Walter L. Straus Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon. Journal of Acquired Immune Deficiency Syndromes. Vol.42, No.2 (2006), 135-139. doi:10.1097/01.qai.0000223017.01568.e7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23745
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Title
Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon
Author(s)
Swati B. Gupta
Christopher T. Mast
Nathan D. Wolfe
Vlad Novitsky
Sheri A. Dubey
Esper G. Kallas
Mauro Schechter
Bernard Mbewe
Eftyhia Vardas
Punee Pitisuttithum
Donald Burke
Dan Freed
Robin Mogg
Paul M. Coplan
Jon H. Condra
Romnie S. Long
Kiersten Anderson
Danilo R. Casimiro
John W. Shiver
Walter L. Straus
Christopher T. Mast
Nathan D. Wolfe
Vlad Novitsky
Sheri A. Dubey
Esper G. Kallas
Mauro Schechter
Bernard Mbewe
Eftyhia Vardas
Punee Pitisuttithum
Donald Burke
Dan Freed
Robin Mogg
Paul M. Coplan
Jon H. Condra
Romnie S. Long
Kiersten Anderson
Danilo R. Casimiro
John W. Shiver
Walter L. Straus
Other Contributor(s)
Merck & Co., Inc.
Johns Hopkins Bloomberg School of Public Health
Harvard School of Public Health
Universidade Federal de Sao Paulo
Universidade Federal do Rio de Janeiro
Malawi College of Medicine
Ministry of Population and Health
University of Witwatersrand
Mahidol University
Intl. Partnership for Microbicides
Merck Research Laboratories
Johns Hopkins Bloomberg School of Public Health
Harvard School of Public Health
Universidade Federal de Sao Paulo
Universidade Federal do Rio de Janeiro
Malawi College of Medicine
Ministry of Population and Health
University of Witwatersrand
Mahidol University
Intl. Partnership for Microbicides
Merck Research Laboratories
Abstract
An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples. Copyright © 2006 by Lippincott Williams & Wilkins.