Publication: Positive diversifying selection on the plasmodium falciparum surf4.1 gene in Thailand
Issued Date
2012-12-27
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ISSN
13494147
13488945
13488945
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2-s2.0-84871443873
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Mahidol University
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SCOPUS
Bibliographic Citation
Tropical Medicine and Health. Vol.40, No.3 (2012), 79-87
Suggested Citation
Phonepadith Xangsayarath, Morakot Kaewthamasorn, Kazuhide Yahata, Shusuke Nakazawa, Jetsumon Sattabongkot, Rachanee Udomsangpetch, Osamu Kaneko Positive diversifying selection on the plasmodium falciparum surf4.1 gene in Thailand. Tropical Medicine and Health. Vol.40, No.3 (2012), 79-87. doi:10.2149/tmh.2012-12 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14410
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Title
Positive diversifying selection on the plasmodium falciparum surf4.1 gene in Thailand
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Abstract
Plasmodiium falciparum SURFIN 4.1 is a type I transmembrane protein thought to locate on the merozoite surface and to be responsible for a reversible adherence to the erythrocyte before invasion. In this study, we evaluated surf4.1 gene segment encoding extracellular region for polymorphism, the signature of positive selection, the degree of linkage disequilibrium, and temporal change in allele frequency distribution in P. falciparum isolates from Thailand in 1988-89, 2003, and 2005. We found that SURFIN 4.1 is highly polymorphic, particularly at the C-terminal side of the variable region located just before a predicted transmembrane region. A signature of positive diversifying selection on the variable region was detected by multiple tests and, to a lesser extent, on conserved N-terminally located cysteine-rich domain by Tajima's D test. Linkage disequilibrium between sites over a long distance ( > 1.5 kb) was detected, and multiple SURFIN 4.1 haplotype sequences detected in 1988/89 still circulated in 2003. Few of the single amino acid polymorphism allele frequency distributions were significantly different between the 1988/89 and 2003 groups, suggesting that the frequency distribution of SURFIN 4.1 extracellular region remained stable over 14 years. © 2012 by The Japanese Society of Tropical Medicine.